General Information

  • ID:  hor004476
  • Uniprot ID:  P81736
  • Protein name:  Tachykinin-related peptide 4
  • Gene name:  NA
  • Organism:  Rhyparobia maderae (Madeira cockroach) (Leucophaea maderae)
  • Family:  Tachykinin family
  • Source:  animal
  • Expression:  Midgut.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Rhyparobia (genus), Oxyhaloinae (subfamily), Blaberidae (family), Blaberoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  APSGFMGMR
  • Length:  9
  • Propeptide:  APSGFMGMR
  • Signal peptide:  NA
  • Modification:  T9 Arginine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myoactive peptide. Increases the amplitude and frequency of spontaneous contractions and tonus of hindgut muscle.
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: 10(-9)M
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004476_AF2.pdbhor004476_ESM.pdb

Physical Information

Mass: 109601 Formula: C40H64N12O11S2
Absent amino acids: CDEHIKLNQTVWY Common amino acids: GM
pI: 10.55 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 2
Hydrophobicity: 7.78 Boman Index: -695
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 11.11
Instability Index: 4331.11 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  8897641
  • Title:  Isolation of Five Tachykinin-Related Peptides From the Midgut of the Cockroach Leucophaea Maderae: Existence of N-terminally Extended Isoforms